Physiologically Based Pharmacokinetic Modeling in Pediatric Drug Development: A Clinician's Request for a More Integrated Approach

1Neonatal Intensive Care Unit, Division of Woman and Child, University Hospitals Leuven, Herestraat 49, 3000 Leuven, Belgium 2Division of Pediatric Clinical Pharmacology, Children’s National Medical Center, Washington, DC, USA 3Departments of Pediatrics, Pharmacology, and Physiology, The School of Medicine and Health Sciences George Washington University, Washington, DC, USA 4 Intensive Care Ward, Erasmus MC-Sophia Children’s Hospital, Rotterdam, The Netherlands